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- Professor of Chemical Biology and CRUK Professorial Fellow
- SoP Pharmaceutical & Bio Chemistry
- UCL School of Pharmacy
- Faculty of Life Sciences
Professor Stephen Neidle is a chemistry graduate of Imperial College, where he also undertook research on the structures of a number of complex natural products and antibiotics (DSc, PhD, ARCS).. After a period as an ICI Fellow, he joined the Biophysics Department at King’s College London, which initiated his interest in nucleic acid structural studies. He was one of the first Cancer Research Campaign Career Development Awardees, and has been a Life Fellow and Professorial Fellow of Cancer Research UK since 2002.
He was appointed to the Chair of Biophysics at the Institute of Cancer Research in 1990 (where he was also Academic Dean 1997-2002) and moved to the School of Pharmacy, University of London in 2002 as the first holder of the new Chair of Chemical Biology. He has also been Research Director of the School.
Stephen Neidle is European Editor of "Bioorganic and Medicinal Chemistry Letters", and is a member of the editorial boards of "Nucleic Acids Research", "Methods" and "Molecular Cancer Therapeutics". He was Chairman of the Editorial Board of Tetrahedron Journals 2011-13, and chaired the RSC Biomolecular Sciences book series. He is currently a member of the Wellcome Trust Peer Review College and The Royal Society Newton Fellows Panel.
Stephen Neidle’s interests are primarily in the chemistry and biology of nucleic acid structure and recognition by small molecules, and in exploiting this information for the rational design of new anti-cancer and anti-infective agents. He has pioneered studies on the structure and recognition of G-quadruplex nucleic acids as novel therapeutic targets, using an integrated multi-disciplinary structural, chemical and biological approach. He has published some 475 papers and reviews, together with 12 patents, and has written and edited a number of books on nucleic acids, drug-DNA interactions and cancer drug discovery. His current h index is 77 in Web of Science (85 in Google Scholar).
An example of his work being translated into new therapeutic agents is given by a novel antibiotic (SMT19969) derived from and closely related to, earlier compounds invented by Stephen Neidle, together with Professor John Mann (formerly at Queen’s University Belfast, now a visiting professor at UCL).
Summit plc, an Oxford, UK based drug discovery company, commenced a Phase I clinical trial for SMT19969 in 2012. This novel orally-available small-molecule antibiotic is selective for the treatment of C. difficile infections. C. difficile is a serious hospital-associated bacterial disease especially affects the elderly and is hard to treat with existing drugs. In 2011 it was responsible for over 2,000 deaths in the UK, and is estimated to cause over 30,000 deaths in the USA. It was announced in April 2013 that the Phase I trial had been concluded, with very successful results. A Phase II clinical trial started in 2014.
SMT19969 itself has been developed by Summit and its biological properties have been characterized in collaboration with the Neidle laboratory. The collaboration was funded by the Wellcome Trust Seeding Drug Discovery fund. SMT19969 shows exceptional selectivity and potency for the bacterium and pre-clinical data has indicated that it has remarkably low toxicity, which has now been confirmed by the Phase I trial.
Work in the Neidle laboratory in the cancer therapeutics area is currently supported by The Pancreatic Cancer Research Fund and Johnson & Johnson Ltd. It is focussed on exploiting the occurrence of quadruplex DNA and RNA sequences in particular regions of the human genome associated with aberrant telomere maintenance, genomic instability or oncogene expression, and targeting these with selective small molecules. Recent work has highlighted this approach to two principal therapeutic areas, targeting pancreatic and renal cancers. Lead compounds have been identified which show high activity in models for pancreatic cancer, and are currently being evaluated for further development.
Teaching is focussed on:
1. lectures on Cancer Drug Discovery in the MSc Drug Discovery course
2. lectures on Research Methods in the PhD course programme
3. undergraduate and MSc research projects