My research is focused on the discovery of novel epigenetic and genetic aberrations that drive T-cell acute lymphoblastic leukaemia (T-ALL), particularly those that impinge on the transcriptional control of proto-oncogenes and tumour suppressors. T-ALL is a haematopoietic malignancy (blood cancer), that arises from the cellular transformation of T-cell progenitors – the cells that mature into functional T-cells. My experiments utilise patient samples, bespoke next-generation sequencing, classical molecular biology and biochemical assays to interrogate T-ALL, in an effort to identify new mechanisms by which this leukaemia occurs. My overall research aim is to use such discoveries to help personalise and stratify treatment for T-ALL.