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Prof Joseph Standing
Prof Joseph Standing profile picture
  • Professor of Pharmacometrics
  • Infection, Immunity & Inflammation Dept
  • UCL GOS Institute of Child Health
  • Faculty of Pop Health Sciences
Research Groups
Research Summary

The major research focus is in using pharmacokinetic/pharmacodynamic modelling to answer questions such as: Does drug X affect disease process Y?  If so, what dose should we recommend?  Often these questions are most challenging when patients are children, and since maturation is a continuous not dichotomous process, understanding appropriate scaling for size and age is important.   Mechanistic, biologically plausible models are fitted using non-linear mixed effects, sometimes using 'priors'. 

Current projects include: Modelling SARS-CoV-2 viral dynamics under antiviral therapy in Phase II trials; Pharmacokinetic/pharmacodynamic studies of antimicrobial and antiviral agents in children; In vitro antimicrobial pharmacodynamics using the hollow fibre infection model; Models for immune reconstitution following bone marrow transplantation in children and personalised pre-transplant conditioning; HIV viral load and CD4 counts in adults and children, and investigating the role of antiretroviral treatment on long-term viral suppression and immune reconstitution; Pharmacokinetic/pharmacodynamic modelling to support antimicrobial stewardship.

The London Pharmacometrics Interest Group holds weekly meetings to discuss this kind of research, more information can be found here: 

Teaching Summary
MSc/MRes module leader of Pharmacometrics CHLD0085. 
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