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Prof Tessa Crompton
Tel: 0207 9052893
Prof Tessa Crompton profile picture
  • Professor of Experimental Immunology
  • Infection, Immunity & Inflammation Dept
  • UCL GOS Institute of Child Health
  • Faculty of Pop Health Sciences
Research Summary
Our research focuses on the control of T cell development in the thymus. The specialized environment of the thymus is essential for efficient production of functional non-self reactive T cells. We aim to understand the way in which signals from the thymic epithelium direct the differentiation of developing T-lineage cells. Currently we are investigating the role of morphogens secreted by the thymic epithelium (Sonic hedgehog (Shh), and Bone morphogenetic protein(BMP)4, in particular) in T cell development. Classical morphogens are secreted signalling molecules that specify cell fate and patterning during embryonic development by providing concentration-dependent positional information. Our work has demonstrated that Shh and BMP4, powerful regulators of embryonic development of many mammalian tissues, also function in the control of self-renewing tissues in the adult, such as the immune system. We showed that Shh and BMP4 are involved in the control of differentiation at multiple stages of T cell development and they now aim to define the molecular events that underlie their functions.
Academic Background
1990   Doctor of Philosophy University College London
1986   Bachelor of Arts University of Oxford
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