The aim of our group is to understand the development of paediatric brain diseases and in particular the roles of neural stem cells in these diseases. We have focussed on brain tumours and epilepsy. Recent highlights include demonstrating how initial mutations cause different types of tumour in the brain and the isolation of a pathological stem cell from a human malformation of cortical development.

Keywords: Brain, Brain Tumour, Cancer, Epilepsy,  Focal Cortical Dysplasia, Morphology, Neural stem cells, Neuroanatomy, Neurogenesis,Neuropathology, Progenitors, Stem cells, Temporal lobes

Conditions: Astrocytoma, Brain tumours in children, Focal Cortical Dysplasia, Epilepsy

Methods: Cell culture, Confocal microscopy, Gene expression profiling - tissue level, Histology, Immunohistochemistry, light microscopic techniques, Time-lapse imaging, Stereological analysis