Email: portico-services@ucl.ac.uk
Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
- Professor of Neuroscience
- Neurodegenerative Diseases
- UCL Queen Square Institute of Neurology
- Faculty of Brain Sciences
After obtaining a BSc (Hons) in Biochemistry from University
College Swansea I subsequently took up a research position at the National
Institute of Medical Research (MRC, Mill Hill), focusing on spinal cord
regeneration under supervision of Professor Geoff Raisman. I then moved to the
Institute of Neurology working under the supervision of Professor Tamas Revesz,
initially studying progressive supranuclear palsy and the different tau
isoforms. The project focus shifted towards two hereditary neurodegenerative
diseases familial British dementia (FBD) and familial Danish dementia (FDD).
Completing my PhD in 2006 investigating the pathology of FBD and FDD providing
detailed information about amyloid formation in the brain in these rare
conditions, which have similar neuropathological features to those of
Alzheimer’s disease (AD) thus providing a model of AD. I am currently focusing my
research on frontotemporal dementias (FTLD) currently funded by the Alzheimer’s
Research UK senior fellowship. FTLD's are a large group of dementia's
characterized by the deposition of several different proteins. Initial work was
carried out to re-diagnose archival cases with the new classifications set out
by the FTLD working group. Comparing the underlying pathology with detailed
clinical histories therefore enabling a more accurate diagnosis in life for
future patients. Work has now progressed into investigating how the
pathological proteins are involved in FTLD, with particular interest in the
proteins TDP-43 and FUS and their role in nuclear transport. My research team
has expanded to cover many different disciplines including neuropathology,
multi-omics approaches and epigenetics to understand the initiating processes
in different neurodegenerative diseases.
I also undertake research and consultancy work with a variety of
funders and clients. If you have a specific enquiry about current research
programmes or the services my team and I can provide, please email me at
T.Lashley@ucl.ac.uk




Assists and lectures on the UCL Dementia MSc (Neuroscience).
Departmental Graduate Tutor (Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology).
01-OCT-2020 | Professor of Neuroscience | Neurodegenerative Disease | UCL Queen Square Institute of Neurology, United Kingdom |
2019 | British Neuropathological Society Secretary | , United Kingdom | |
2019 | Director of Research at Queen Square Brain Bank | UCL Queen Square Institute of Neurology, United Kingdom | |
2016 – 2021 | Alzheimer's Research UK Senior Research Fellow | Neurodegenerative Disease | UCL Queen Square Institute of Neurology, United Kingdom |
2013 – 2016 | Alzheimer's Research UK Fellow | Molecular Neuroscience | UCL Queen Square Institute of Neurology, United Kingdom |
2006 | Doctor of Philosophy | Institute of Neurology | |
1995 | Bachelor of Science (Honours) | University of Wales, Swansea |