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Professor Tammaryn Lashley
Queen Square Brain Bank
1 Wakefield Street
London
WC1N 1PJ
Tel: 0207 679 4194
Professor Tammaryn Lashley profile picture
Appointment
  • Professor of Neuroscience
  • Neurodegenerative Diseases
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences
Biography

After obtaining a BSc (Hons) in Biochemistry from University College Swansea I subsequently took up a research position at the National Institute of Medical Research (MRC, Mill Hill), focusing on spinal cord regeneration under supervision of Professor Geoff Raisman. I then moved to the Institute of Neurology working under the supervision of Professor Tamas Revesz, initially studying progressive supranuclear palsy and the different tau isoforms. The project focus shifted towards two hereditary neurodegenerative diseases familial British dementia (FBD) and familial Danish dementia (FDD). Completing my PhD in 2006 investigating the pathology of FBD and FDD providing detailed information about amyloid formation in the brain in these rare conditions, which have similar neuropathological features to those of Alzheimer’s disease (AD) thus providing a model of AD. I am currently focusing my research on frontotemporal dementias (FTLD) currently funded by the Alzheimer’s Research UK senior fellowship. FTLD's are a large group of dementia's characterized by the deposition of several different proteins. Initial work was carried out to re-diagnose archival cases with the new classifications set out by the FTLD working group. Comparing the underlying pathology with detailed clinical histories therefore enabling a more accurate diagnosis in life for future patients. Work has now progressed into investigating how the pathological proteins are involved in FTLD, with particular interest in the proteins TDP-43 and FUS and their role in nuclear transport. My research team has expanded to cover many different disciplines including neuropathology, multi-omics approaches and epigenetics to understand the initiating processes in different neurodegenerative diseases.


 

I also undertake research and consultancy work with a variety of funders and clients. If you have a specific enquiry about current research programmes or the services my team and I can provide, please email me at T.Lashley@ucl.ac.uk


Research Groups
Research Themes
Teaching Summary

Assists and lectures on the UCL Dementia MSc (Neuroscience).

Departmental Graduate Tutor (Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology).


Appointments
01-OCT-2020 Professor of Neuroscience Neurodegenerative Disease UCL Queen Square Institute of Neurology, United Kingdom
2019 British Neuropathological Society Secretary    , United Kingdom
2019 Director of Research at Queen Square Brain Bank   UCL Queen Square Institute of Neurology, United Kingdom
2016 – 2021 Alzheimer's Research UK Senior Research Fellow Neurodegenerative Disease UCL Queen Square Institute of Neurology, United Kingdom
2013 – 2016 Alzheimer's Research UK Fellow Molecular Neuroscience UCL Queen Square Institute of Neurology, United Kingdom
Academic Background
2006   Doctor of Philosophy Institute of Neurology
1995   Bachelor of Science (Honours) University of Wales, Swansea
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