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Prof Troy Margrie
Prof Troy Margrie profile picture
  • Professor of Systems Neuroscience and Associate Director
  • The Sainsbury Wellcome Centre
  • Faculty of Life Sciences
Research Groups
Research Themes
Research Summary

Perhaps the two most compelling features of the brain are its complex interconnectivity within and between the different parts of the brain, and the myriad types of cell needed to carry out everything the brain is capable of. Our lab is dedicated to mapping the connections within and across these two features—the ways that different classes of cells and the systems they form work together. We believe that only with a quantitative understanding of the heterogeneity of both connectivity and cellular / functional composition, will we be able to elucidate key principles underlying the design and operation of both the healthy and the diseased brain.

We employ a variety of technical approaches, some of which are multidisciplinary and/or were developed in our lab. These include 3D electron microscopic analysis, in vitro and in vivo single and multi-cell targeted recordings, whole-brain connectivity mapping of recorded cells, optogenetics, modelling, and behaviour. Our lab works almost exclusively on mice, which offer a tractable experimental system for establishing causal relationships between the functional connectivity of mammalian neuronal circuits and behaviour.

FEB-2015 Associate Director   Sainsbury Wellcome Centre, United Kingdom
01-AUG-2009 – 01-AUG-2020 Honorary Professor Neurosciemce, Physiology and Pharmacology University College London, United Kingdom
Academic Background
1998   Doctor of Philosophy University of Newcastle
1994   Bachelor of Science (Honours) University of Newcastle
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