My main research interests lie in cancer drug development, with a particular focus on Hepatocellular Carcinoma (HCC) and Neuroendocrine Tumours (NET). I run a specialist clinic in these tumour types at the Royal Free Hospital and an ‘Early-Phase Trial’ Clinic at the NIHR Wellcome UCH Clinical Research Facility. In addition to leading an extensive clinical trial portfolio, I have integrated biomarker research into my clinical practice and this has increasingly focused on the role of Circulating Tumour Cell (CTCs) as predictive and prognostic markers of disease. My current research projects include defining the role of CTCs as pharmacodynamic markers and surrogates for molecular profiling of tumours in the context of drug development.

I am the Cancer Director of the NIHR Wellcome UCH Clinical Research Facility and the Joint Director of the UCL ECMC. Nationally, I Chair the TRANSNET Committee. In addition, I am a member of the UKNETS Steering Committee and I sit on both the Hepatobiliary and NET NIHR Clinical Studies Sub-Groups.