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Prof Timothy Arnett
Anatomy Building, UCL
Gower Street
London
WC1E 6BT
Prof Timothy Arnett profile picture
Appointment
  • Professor of Mineralised Tissue Biology
  • Cell & Developmental Biology
  • Div of Biosciences
  • Faculty of Life Sciences
Research Summary

The skeleton is a surprisingly dynamic tissue that remodels throughout life in humans.  I study factors that control the function of the three main bone cell types: osteoblasts (bone-forming connective tissue cells), osteocytes (network of ex-osteoblasts resident in bone matrix) and osteoclasts (specialised bone-destroying cells, derived from haematopoietic system).  I am particularly interested in two ‘fundamental’ regulators, hypoxia and acidosis, which are, respectively, major stimulators of the formation and resorptive (destructive) activities of osteoclasts.  At the same time, hypoxia and acidosis exert profound reciprocal actions on osteoblasts by respectively blocking their growth / differentiation (and thus bone formation) and ability to mineralise bone.  These responses provide insights into the pathogenesis of common bone loss disorders.  A separate line of research is focussed on the ability of extracellular ATP to block mineralisation in bone and vascular smooth muscle.  This effect appears to be partly mediated by P2 receptors for ATP but, perhaps more importantly, via the enzymic breakdown of ATP outside cells to produce pyrophosphate, the body’s ubiquitous ‘natural water softener’.

Teaching Summary

Bone / cartilage / digital histology / imaging. Initiatives with Bone Research Society; European Calcified Tissue Society

Academic Background
1984   Doctor of Philosophy University of London
1974   Bachelor of Science (Honours) University of East Anglia
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