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Prof Tamas Revesz
1 Wakefield Street
London
WC1N 1PJ
Appointment
  • Principal Clinical Research Associate
  • Neurodegenerative Diseases
  • Institute of Neurology
  • Faculty of Brain Sciences
  • Institute of Neurology
  • Faculty of Brain Sciences
Biography

Research

As an academic neuropathologist my research has mainly focused on understanding pathomechanism of neurodegenerative diseases. The major topics pursued in the past 12 years include:

1. Cerebral amyloid formation and neurodegeneration

  • Papers in Nature, Proc Natl Acad Sci, Brain, Ann Neurol, Am J Pathol, J Biol Chem, J Neuropathol Exp Neurol, Acta Neuropathol, Neuropathol Appl Neurobiol
2. Frontotemporal lobar degeneration

  • Papers in Brain, Acta Neuropathol, Neurology, Neuropathol Appl Neurobiol
3. Parkinson’s disease: disease spread, factors influencing disease manifestation

  • Papers in Nat Med, Nat Rev Neurosci, Lancet, Brain, Ann Neurol, Acta Neuropathol
4. Clinical, genetic, biochemical and pathological subgroups in progressive supranuclear palsy

  • Papers in Brain, Nat Genetics, Ann Neurol, Mov Disord, FEBS Lett
ResearcherID: http://www.researcherid.com/rid/A-8732-2010 

Research Groups
Research Themes
Research Summary

Research at the Queen Square Brain Bank for Neurological Disorders includes studies on Parkinson's disease. In one such collaborative study, carried out by several groups of the Department of Molecular Neuroscience, UCL Institute of Neurology, we characterized the expression of PINK1 protein in normal human and sporadic Parkinson's disease brains in addition to Parkinson's cases with heterozygous PINK1 mutations. With brain fractionation studies we confirmed that PINK1 is localized to the mitochondrial membranes. In addition, we showed that PINK1 is present in a proportion of Lewy bodies in cases of sporadic Parkinson's disease and Parkinson's disease associated with heterozygous mutations in the PINK1 gene. Our studies provided for the first time in vivo morphological and biochemical evidence to support a mitochondrial localization of PINK1 and support the significance of mitochondrial dysfunction in the pathogenesis of Parkinson's disease. Alpha synuclein is studied in relation to sporadic Parkinson's disease. By studying Parkinson cases, which were treated in life with transplantation of human embryonal mesencephalic dopaminergic cells into the patients striatum, we were able to show that the disease spreads from the host to graft.

The large, well documented case collection of the QSBB has also permitted detailed clinicopathological studies of different movement disorders, such as multiple system atrophy, progressive supranuclear palsy and frontotemporal dementias. In studies on progressive supranuclear palsy we were able to demonstrate an association between cerebral accumulation of hyperphosphorylated tau and clinical phenotypes. Examples of rare diseases in the collection have led to the identification of their genetic abnormalities and/or enabled us to perform detailed description and study of entities such as the familial British and familial Danish dementias and neurofilament inclusion body disease.

Teaching Summary

I contribute to postgraduate teaching by lectures and supervision of MSc and PhD projects. The well-attended monthly clinicopathological conferences, organised by Queen Square Brain Bank, are an important aspect of  postgraduate teaching at the National Hospital and UCL Institute of Neurology.   

Appointments
2004 Professor of Neuropathology UCL Institute of Neurology UCL, United Kingdom
2002 Director, Queen Square Brain Bank for Neurological Disorders Department of Molecular Neuroscience UCL Institute of Neurology, United Kingdom
2001 – 2004 Reader in Neuropathology UCL Institute of Neurology UCL, United Kingdom
1991 Honorary Consultant Neuropathologist Division of Neuropathology The National Hospital for Neurology and Neurosurgery, United Kingdom
1991 – 2001 Senior Lecturer in Neuropathology UCL Institute of Neurology UCL, United Kingdom
Academic Background
1999 FRCPath Fellow of the Royal College of Pathologists – Medicine Royal College of Pathologists, UK
1990 MRCPath Member of the Royal College of Pathologists – Medicine Royal College of Pathologists, UK
1972 MD Doctor of Medicine – Medicine Semmelweis Medical School
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