Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Lucy van Dorp
Room 212
UCL Department of Genetics, Evolution & Environment/UCL Genetics Institute
Darwin Building, Gower Street
Dr Lucy van Dorp profile picture
  • Senior Research Fellow
  • Genetics, Evolution & Environment
  • Div of Biosciences
  • Faculty of Life Sciences
Research Summary

My research aims to contribute to the post-genomic revolution in biology and medicine through the use of computational methods applied to whole genome sequencing data to determine the factors giving rise to the patterns of genetic diversity we observe in human-associated pathogens. As a computational biologist, with a PhD in population genetics, my work draws across methodological disciplines, including phylogenetics and machine learning. 

Currently, my work focuses on reconstructing the evolutionary history of significant infectious diseases, including COVID-19, Tuberculosis,  Malaria and multidrug-resistant hospital infections. Through the development and application of computational methods I infer the key factors which contribute to the emergence, spread and transmission of bacterial,  viral, fungal and eukaryotic pathogens. I aim to place these reconstructions in strong societal and historical context. This requires addressing to what extent the spread of a specific disease might be closely linked to human or animal movements, subsistence practices and trade, but also considers the effect of the introduction of a specific drug or the choice of drug treatment in the clinic. 

Therefore my research also covers human demography, migration and admixture history and ultimately aims to connect us to our interactions with infectious disease at both recent eg. the emergence of antimicrobial resistant bacteria and ancient eg. human population structure at the time of the Neolithic revolution, time-scales. 

My main interests are:
  • Human and bacterial (pathogen) population genetics 
  • Haplotype-based methods to infer human demography eg. CHROMOPAINTER and fineSTRUCTURE and to identify, characterise and date admixture/introgression events eg. GLOBETROTTER 
  • Ancient DNA (aDNA) as a tool for exploring evolution at deep time scales  
  • Antimicrobial resistance (AMR) in gram negative bacteria  
  • Transmission chain reconstruction, understanding the emergence and spread of outbreaks 
  • Metagenomic screening tools for rapid diagnostics and taxonomic characterisation of species from modern clinical samples to degraded (museum/ancient) sequences

Teaching Summary

  • Lectures and practicals delivered for BIOL0021 Advanced Human Genetics and BIOL0034 Applications in Human Genetics.
  • Guest lecturer on MEDC0027 The Human Microbiome in Health and Disease, INIM0015 Evolution & Infectious Diseases, BIOL0003 Introduction to Genetics and MEDC0108 Advanced Bacteriology.
  • Lectures and practicals on GLB0034 Molecular Epidemiology of Infectious Diseases.
  • I also assist on GENE0001 Human Genetics Core Skills and offer projects as part of the MSc Genetics of Human Disease.

Academic Background
2017   Doctor of Philosophy University College London
2011   Bachelor of Science (Honours) Royal Holloway
    ATQ02 - Recognised by the HEA as an Associate Fellow  
2013   Master of Research University College London
2012   Master of Science University College London/Imperial College
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by