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Dr Victoria Male
2/23
Institute of Immunity and Transplantation
Rowland Hill Street
London
NW3 2PF
Tel: 02077940500 x34064
Appointment
  • Sir Henry Dale Fellow
  • Div of Infection & Immunity
  • Faculty of Medical Sciences
Biography
I undertook my PhD with Ashley Moffett at the University of Cambridge, working on the origin and development of NK cells in the human uterus. In 2011 I moved to Hugh Brady’s lab at Imperial College London, where I worked with mice deficient for a variety of transcription factors in order to better understand the transcriptional control of NK cell development in the bone marrow, liver and thymus. I was awarded a Royal Society/Wellcome Trust Sir Henry Dale Fellowship in 2015 and came to UCL to start my own research group.
Research Themes
Research Summary

I am an immunologist with a long-standing interest in the development and function of natural killer (NK) cells and innate lymphoid cells (ILCs). I am currently a Royal Society and Wellcome Trust-funded Sir Henry Dale Fellow, running a small research group at the Institute of Immunity and Transplantation, UCL Medical School.

Recently, a number of groups have identified liver-resident NK cells (which are sometimes considered to be helper ILC1) in mice. The first major paper to come out of my research group examined peripheral blood and intrahepatic NK cells from recipients of HLA-mismatched liver transplants to show that an equivalent, liver-resident NK cell is also present in humans (Cuff et al, 2016, J Immunol). We further showed that the precursors of liver-resident NK cells can be recruited from the blood during adult life and defined conditions that can convert circulating NK cells to cells with a liver-resident phenotype. Our goal now is to define the function of these cells, both in humans and in mice.

I also run the Institute’s seminar programme.

Appointments
01-MAR-2015 Sir Henry Dale Fellow Institute of Immunity and Transplantation UCL, United Kingdom
16-OCT-2014 – 28-FEB-2015 Post-doctoral Research Associate Division of Cancer Studies King's College London, United Kingdom
01-DEC-2010 – 30-NOV-2013 Post-doctoral Research Associate Department of Life Sciences Imperial College London, United Kingdom
01-OCT-2007 – 30-SEP-2010 PhD Student Department of Pathology University of Cambridge, United Kingdom
Academic Background
2011 PhD Doctor of Philosophy – Immunology University of Cambridge
2007 BA Bachelor of Arts – Natural Sciences University of Cambridge
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