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Dr Wei-Li Di
30 Guilford Street
Fax: 020 78138494
  • Senior Lecturer
  • ICH Infect, Imm, Infla. & Physio Med
  • UCL GOS Institute of Child Health
  • Faculty of Pop Health Sciences
Research Summary

My interests are on rare skin diseases such as Netherton syndrome and a far more common disease atopic eczema. I want, through my research, to understand the patho-mechanisms underlying these conditions and develop more specific treatments for these diseases.

I have been studying the relationship of dysfunctional skin barrier and serine protease activity in atopic eczema, and developing a specific molecule to control the activity of serine protease activity. We are expecting that the outcomes of the research will potentially lead to treatment by offering a new way to attack the skin barrier function defect. We also hope that the research can provide new insight into how proteases contribute to skin pathology.  

In addition to this, our research team has been on the development of gene therapy strategies for genetic skin diseases and the research results have directly led to the initiation of translational developments for first in man gene therapy studies. We undertake GMP production of lentiviral skin grafts, and are well placed to lead the field in this area.

Academic Background
1996 PhD Doctor of Philosophy Queen Mary College, University of London
1983 MBBS Bachelor of Medicine/Bachelor of Surgery – Clinical Medicine Shanghai Medical University
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