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Prof Waseem Qasim
30 Guilford St
  • Professor of Cell and Gene Therapy
  • ICH Infect, Imm, Infla. & Physio Med
  • UCL GOS Institute of Child Health
  • Faculty of Pop Health Sciences

2003-2007 Leukaemia Research Fund clinician scientist/lecturer in Paediatric Immunology/ Bone marrow transplantation, Institute of Child Health & Great Ormond Street Hospital, London

2007-2012 LLR/ICH Senior Clinical Lecturer, Institute of Child Health & Great Ormond Street Hospital, London

2012- 2015 Reader in Cell & Gene Therapy, Institute of Child Health & Great Ormond Street Hospital, London

2015-  NIHR Professor of cell and gene therapy developing next generation T cell gene therapies.

Research Summary

Development and application of genome editing and gene based therapies.
  • I have a special interest T lymphocytes and how they can be used for powerful new therapies. My research at ICH/Great Ormond Street Hospital is centred on diagnosing and treating immune disorders, haematopoietic stem cell transplantation (HSCT) and gene based therapies for leukaemia and other conditions.
  • Lab projects are developing and testing viral vectors and gene editing reagents including TALENs and CRISPR/Cas9. Some of these are in clinical phase testing.
  • We are characterising cellular immune recovery after transplantation and investigating umbilical cord blood T cells.
  • My laboratory has a pipeline of vector development including gamma retroviral, lentiviral and transposon based systems, from initial development through to production at GMP.  
  • Development of genome editing and base editing for therapy is underway.
  • The procedures have also been adapted for gene therapy for skin disorders. We have recently completed trials of gene corrected skin grafts for Nethertons syndrome and a trial for Epidermolysis Bullosa using engineered fibroblasts.

Teaching Summary

1. UCL- MSc Clinical Cell & Gene Therapy, module organiser and lecturer (2011)  
2. UCL-Lecturer MSc Human Genetics, Disease to gene therapy, BIOL3013 (2005-2010)
3. UCL-Lecturer on MRes in Biomedicine course,Gene Therapy for Immunodeficiency (2003-2010)
4. UCL- Lecturer on MSc in Paediatrics course,Cell and gene therapy for cancer (2007-2009)

01-OCT-2015 NIHR professor of cell and gene therapy   Institute of Child Health, United Kingdom
01-OCT-2012 – 30-SEP-2015 Reader in Cell & Gene Therapy Institute of Child Health UCL, United Kingdom
01-APR-2007 Senior Clinical Lecturer Molecular Immunology Institute of child health, United Kingdom
Academic Background
2003 PhD Doctor of Philosophy – Gene Therapy University College London
1997 MRCPCH Member of the Royal College of Paediatrics and Child Health – Paediatrics and Child Health Royal College of Paediatrics and Child Health
1996 MRCP Member of the Royal College of Physicians – Paediatrics and Child Health Royal College of Physicians
1993 BMEDSCI Bachelor of Medical Science – Immunology University of Newcastle upon Tyne
1993 MBBS Bachelor of Medicine/Bachelor of Surgery – Medicine Newcastle University
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