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Prof Waseem Qasim
30 Guilford St
  • Professor of Cell and Gene Therapy
  • ICH Infect, Imm, Infla. & Physio Med
  • UCL GOS Institute of Child Health
  • Faculty of Pop Health Sciences

2003-2007 Leukaemia Research Fund clinician scientist/lecturer in Paediatric Immunology/ Bone marrow transplantation, Institute of Child Health & Great Ormond Street Hospital, London

2007-2012 LLR/ICH Senior Clinical Lecturer, Institute of Child Health & Great Ormond Street Hospital, London

2012- 2015 Reader in Cell & Gene Therapy, Institute of Child Health & Great Ormond Street Hospital, London

Research Summary

  • My research at ICH/Great Ormond Street Hospital is centred on diagnosing and treating immune disorders, improving immune recovery after haematopoietic stem cell transplantation (HSCT) and gene based therapies.
  • I have a special interest T lymphocytes and how they can be used to control virus infections and certain malignant conditions. 
  • Lab projects are developing and testing viral vectors and gene editing reagents including TALENs and CRISPRs. Some of these are close to clinical phase application.
  • We are characterising cellular immune recovery after transplantation and investigating umbilical cord blood T cells (Dr Paul Veys)
  • A number of clinical studies are using vector technologies, clean room facilities and procedures we have developed for human cell therapies (Prof Adrian Thrasher, Prof Bobby Gaspar)(i) A trial of virus specific T cells to treat children with Adenovirus and Cytomegalovirus after HSCT; (ii) suicide gene modified cells after haploidentical transplantation; (iii) the production of T cell receptor modified T (Prof Hans Stauss, Dr Emma Morris) and chimeric antigen receptor expressing T cells (Dr Martin Pule).
  • My laboratory has a pipeline of vector development including gamma retroviral, lentiviral and transposon based systems, from initial development through to production at GMP (with Prof Farzin Farzenah).  
  • Experience with lentiviral vectors has produced interesting new possibilities for the treatment of HIV using novel TRIM-Cylcophilin restriction factors (with Prof Greg Towers, Prof Nigel Klein).
  • The procedures that developed for harvesting, manipulation and engineering of human immune cells have also been adapted for gene therapy for skin disorders. We have recently started a trial of gene corrected skin grafts for Nethertons syndrome (Dr Wei Di, Dr Jemima Mellerio, Prof John Harper) and will shortly open a trial for     Epidermolysis Bullosa using engineered fibroblasts (Prof John McGrath).

Teaching Summary

1. UCL- MSc Clinical Cell & Gene Therapy, module organiser and lecturer (2011)  
2. UCL-Lecturer MSc Human Genetics, Disease to gene therapy, BIOL3013 (2005-2010)
3. UCL-Lecturer on MRes in Biomedicine course,Gene Therapy for Immunodeficiency (2003-2010)
4. UCL- Lecturer on MSc in Paediatrics course,Cell and gene therapy for cancer (2007-2009)

01-OCT-2012 – 30-SEP-2015 Reader in Cell & Gene Therapy Institute of Child Health UCL, United Kingdom
01-APR-2007 Senior Clinical Lecturer Molecular Immunology Institute of child health, United Kingdom
Academic Background
2003 PhD Doctor of Philosophy – Gene Therapy University College London
1997 MRCPCH Member of the Royal College of Paediatrics and Child Health – Paediatrics and Child Health Royal College of Paediatrics and Child Health
1996 MRCP Member of the Royal College of Physicians – Paediatrics and Child Health Royal College of Physicians
1993 BMEDSCI Bachelor of Medical Science – Immunology University of Newcastle upon Tyne
1993 MBBS Bachelor of Medicine/Bachelor of Surgery – Medicine Newcastle University
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