Yuhong Zhou leads the bioprocess modelling research in the Innovative Manufacturing Research Centre (IMRC) in Bioprocessing. The research in this area has played an important role in the faster creation of biomanufacturing processes at lower cost. Collaborating with Prof. Nigel Titchener-Hooker, Prof. Mike Hoare and Dr. Dan Bracewell in the IMRC programme, her modelling research is integrated closely with ultra scale-down and microwell techniques to develop Intelligent Design of Experiment (IDoE) methods for the rapid creation of whole bioprocesses. The research also focuses on the development of fast analytical tools such as Windows of Operation and Robust Operation Strategies for the whole bioprocess which aims to provide industry with a new opportunity to more readily embrace bioprocess optimization tools. Collaboration with one of the IMRC industrial partners (BioPharm Services) has led to a tool for assessing the solutions in chromatographic process design and operation for large-scale manufacture. Yuhong’s research interest in plant-wise management of bioprocessing manufacture has led her to create agent-based methods for efficient communication and real-time decision-making to improve the performance of manufacturing processes by collaborating with Prof. Nigel Titchener-Hooker and Prof. Gary Montague and Dr Jarka Glassey at Newcastle University . S he is also interested in the development of bioprocess knowledge base through collaboration with Dr Anthony Hunter in the UCL Computer Science department. Collaborating with Prof. John Ward (Biochemistry and Molecular Biology) and Dr. Frank Baganz, her research in Metabolic Network Modelling strives to obtain an enhanced understanding of the metabolism and cellular functions by metabolic modelling and simulation of a whole cell. Based on the metabolic flux analysis studies, targets will be identified for pathway manipulation and the required biological changes determined in order to achieve good performance in fermentation. Funding for the above research has come from the UK EPSRC and BBSRC and a range of company collaborators.