Please report any queries concerning the funding data grouped in the
sections named
"Externally Awarded"
or
"Internally Disbursed"
(shown on the profile page) to your Research Finance Administrator.
Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php
by entering your department
Please report any queries concerning the student data shown on the
profile page to:
Email: portico-services@ucl.ac.uk
Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Email: portico-services@ucl.ac.uk
Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
› More
search options
Dr Cheng Zhang
Room 3.01
Bernard Katz Building
Gower Street
London
WC1E 6BT
Appointment
- Research Associate
- Dept of Biochemical Engineering
- Faculty of Engineering Science
Biography
Cheng is a team member of EPSRC funding "Enabling rapid liquid and freeze-dried formulation design for the manufacture and delivery of novel biopharmaceuticals". He participates in an Innovate UK secondment program with Ipsen. He is a Member of Royal Society of Chemistry (MRSC).
Research Summary
Protein Engineering and Formulation Optimisation
- Use Rosetta to identify the unstable residues of Fab and propose stabilising mutations
- In vitro express and purify the Fab variants
- Validate the variants’ stability by melting temperature (Tm) and aggregation kinetics
- Stabilise the Fab through increased concentration (DLS, SLS, viscosity, crowding agents)
- Molecular dynamics to decipher the conformational variability
- Coordinate the Teams Group "Protein Structure Modelling"
Crystallisation
- Screen out the potential crystallisation conditions for Fab
- Resolve the X-ray structure and deposit to PDB
- Determine the structural alteration in Fab variants and formulation conditions
Freeze-drying
- Coordinate a freeze-drying training course in UCL with Biopharma company
- Optimise the freeze-drying for Oxford ChAdOx1 vaccine
Teaching Summary
- 2020-2021
Module Title: Research Skills
Position: Teaching Assistant
Module code: BENG0097
Module Title: Bioprocess Recovery and Purification/Biochemical Engineering Laboratory
Position: Teaching Assistant for Pilot Plant Week (PPW) Scenario
Module code: BENG0056
- 2019-2020
Module Title: Bioprocess Recovery and Purification/Biochemical Engineering Laboratory
Position: Teaching Assistant for Pilot Plant Week (PPW) Scenario
Module code: BENG0012/BENG0009/BENG0096
Module Title: Research Skills
Position: Teaching Assistant
Module code: BENG0097
Help the molecular dynamic simulation for the UCL iGEM 2019 Team
- 2018-2019
Module Title: Pilot Plant Week (PPW) Scenario
Position: Teaching Assistant
Module code: BENG201P
- 2017-2018
Module Title: Pilot Plant Week (PPW) Scenario
Position: Teaching Assistant
Module code: BENG201P
Academic Background
| Doctor of Philosophy | University College London | ||
| 2011 | Bachelor of Engineering | Zhejiang University of Technology | |
| Master of Research | University College London |
