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Dr Cheng Zhang
Room 3.01
Bernard Katz Building
Gower Street
London
WC1E 6BT
Appointment
  • Research Associate
  • Dept of Biochemical Engineering
  • Faculty of Engineering Science
Biography

Cheng is a team member of EPSRC funding "Enabling rapid liquid and freeze-dried formulation design for the manufacture and delivery of novel biopharmaceuticals". He participates in an Innovate UK secondment program with Ipsen. He is a Member of Royal Society of Chemistry (MRSC).

Research Summary

Protein Engineering and Formulation Optimisation
  • Use Rosetta to identify the unstable residues of Fab and propose stabilising mutations
  • In vitro express and purify the Fab variants
  • Validate the variants’ stability by melting temperature (Tm) and aggregation kinetics
  • Stabilise the Fab through increased concentration (DLS, SLS, viscosity, crowding agents)
  • Molecular dynamics to decipher the conformational variability
  • Coordinate the Teams Group "Protein Structure Modelling"

Crystallisation
  • Screen out the potential crystallisation conditions for Fab
  • Resolve the X-ray structure and deposit to PDB
  • Determine the structural alteration in Fab variants and formulation conditions

Freeze-drying 
  • Coordinate a freeze-drying training course in UCL with Biopharma company
  • Optimise the freeze-drying for Oxford ChAdOx1 vaccine

Teaching Summary

  • 2020-2021
Module Title: Research Skills
Position: Teaching Assistant
Module code: BENG0097

Module Title: Bioprocess Recovery and Purification/Biochemical Engineering Laboratory
Position: Teaching Assistant for Pilot Plant Week (PPW) Scenario
Module code: BENG0056

  • 2019-2020
Module Title: Bioprocess Recovery and Purification/Biochemical Engineering Laboratory
Position: Teaching Assistant for Pilot Plant Week (PPW) Scenario
Module code: BENG0012/BENG0009/BENG0096

Module Title: Research Skills
Position: Teaching Assistant
Module code: BENG0097

Help the molecular dynamic simulation for the UCL iGEM 2019 Team

  • 2018-2019
Module Title: Pilot Plant Week (PPW) Scenario
Position: Teaching Assistant
Module code: BENG201P

  • 2017-2018
Module Title: Pilot Plant Week (PPW) Scenario
Position: Teaching Assistant
Module code: BENG201P

Academic Background
    Doctor of Philosophy University College London
2011   Bachelor of Engineering Zhejiang University of Technology
    Master of Research University College London
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