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Dr Cheng Zhang
Room 3.01
Bernard Katz Building
Gower Street
London
WC1E 6BT
Appointment
- Research Associate
- Dept of Biochemical Engineering
- Faculty of Engineering Science
Biography
Cheng is a team member of EPSRC funding "Enabling rapid liquid and freeze-dried formulation design for the manufacture and delivery of novel biopharmaceuticals". He undertakes an Innovate UK secondment program for Botulinum toxin (BoNT) with Ipsen. He is a Member of Royal Society of Chemistry (MRSC).
Research Summary
Protein Engineering and Formulation Optimisation
- Computational modelling for the Botulinum toxin (BoNT), Targeted Secretion Inhibitors (TSI) and single-domain antibodies (VHH)
- Computational modelling for the A33 Fab, including Rosetta and molecular dynamics (Gromacs)
- In silico identify the unstable residues of Fab and propose stabilising mutations
- In vitro express and purify the Fab variants
- Validate the variants’ stability by melting temperature (Tm) and aggregation kinetics
- Stabilise the Fab through increased concentration (DLS, SLS, viscosity, crowding agents)
Crystallisation
- Screen out the potential crystallisation conditions for Fab
- Resolve the X-ray structure and deposit to PDB (7NFA, 7NC0)
- Determine the structural alteration in Fab variants and formulation conditions
Freeze-drying
- Coordinate a freeze-drying training course in UCL with Biopharma company
- Develop a freeze-dried dosage form for the Oxford-AstraZeneca ChAdOx1 COVID-19 vaccine
Teaching Summary
- 2021-2022
Module Title: Research Skills
Position: Teaching Assistant
Module code: BENG0097
- 2020-2021
Module Title: Research Skills
Position: Teaching Assistant
Module code: BENG0097
Module Title: Bioprocess Recovery and Purification/Biochemical Engineering Laboratory
Position: Teaching Assistant for Pilot Plant Week (PPW) Scenario
Module code: BENG0056
- 2019-2020
Module Title: Bioprocess Recovery and Purification/Biochemical Engineering Laboratory
Position: Teaching Assistant for Pilot Plant Week (PPW) Scenario
Module code: BENG0012/BENG0009/BENG0096
Module Title: Research Skills
Position: Teaching Assistant
Module code: BENG0097
Help the molecular dynamic simulation for the UCL iGEM 2019 Team
- 2018-2019
Module Title: Pilot Plant Week (PPW) Scenario
Position: Teaching Assistant
Module code: BENG201P
- 2017-2018
Module Title: Pilot Plant Week (PPW) Scenario
Position: Teaching Assistant
Module code: BENG201P
Academic Background
| Doctor of Philosophy | University College London | ||
| 2011 | Bachelor of Engineering | Zhejiang University of Technology | |
| Master of Research | University College London |
