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Dr Cheng Zhang
Room 3.01
Bernard Katz Building
Gower Street
London
WC1E 6BT
Dr Cheng Zhang profile picture
Appointment
  • Research Associate
  • Dept of Biochemical Engineering
  • Faculty of Engineering Science
Biography

Cheng is a team member of EPSRC funding "Enabling rapid liquid and freeze-dried formulation design for the manufacture and delivery of novel biopharmaceuticals". He undertakes an Innovate UK secondment program for Botulinum toxin (BoNT) with Ipsen. He is a Member of Royal Society of Chemistry (MRSC).

Research Summary

Protein Engineering and Formulation Optimisation

  • Computational modelling for the Botulinum toxin (BoNT), Targeted Secretion Inhibitors (TSI) and single-domain antibodies (VHH)
  • Computational modelling for the A33 Fab, including Rosetta and molecular dynamics (Gromacs)
  • In silico identify the unstable residues of Fab and propose stabilising mutations
  • In vitro express and purify the Fab variants
  • Validate the variants’ stability by melting temperature (Tm) and aggregation kinetics
  • Stabilise the Fab through increased concentration (DLS, SLS, viscosity, crowding agents)


Crystallisation

  • Screen out the potential crystallisation conditions for Fab
  • Resolve the X-ray structure and deposit to PDB (7NFA, 7NC0)
  • Determine the structural alteration in Fab variants and formulation conditions


Freeze-drying 

  • Coordinate a freeze-drying training course in UCL with Biopharma company
  • Develop a freeze-dried dosage form for the Oxford-AstraZeneca ChAdOx1 COVID-19 vaccine

Teaching Summary

  • 2021-2022

Module Title: Research Skills

Position: Teaching Assistant

Module code: BENG0097


  • 2020-2021

Module Title: Research Skills

Position: Teaching Assistant

Module code: BENG0097


Module Title: Bioprocess Recovery and Purification/Biochemical Engineering Laboratory

Position: Teaching Assistant for Pilot Plant Week (PPW) Scenario

Module code: BENG0056


  • 2019-2020

Module Title: Bioprocess Recovery and Purification/Biochemical Engineering Laboratory

Position: Teaching Assistant for Pilot Plant Week (PPW) Scenario

Module code: BENG0012/BENG0009/BENG0096


Module Title: Research Skills

Position: Teaching Assistant

Module code: BENG0097


Help the molecular dynamic simulation for the UCL iGEM 2019 Team


  • 2018-2019

Module Title: Pilot Plant Week (PPW) Scenario

Position: Teaching Assistant

Module code: BENG201P


  • 2017-2018

Module Title: Pilot Plant Week (PPW) Scenario

Position: Teaching Assistant

Module code: BENG201P

Academic Background
    Doctor of Philosophy University College London
2011   Bachelor of Engineering Zhejiang University of Technology
    Master of Research University College London
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