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Investigating the mechanisms underlying bariatric surgery
Bariatric surgery is the most effective treatment option for obesity resulting in substantial and durable weight loss, with reduction in mortality and obesity-related co-morbidities. Obesity is the primary risk factor for type 2 diabetes mellitus (T2DM) which is characterised by insufficient insulin secretion and insulin resistance. Proximal gastric bypass surgery (PGBP) and sleeve gastrectomy (SG) reduce excess bodyweight by up to 80%. Additionally, the majority of individuals with T2DM that undergo PGBP show immediate improved glycaemic control following surgery, before significant weight loss. Whilst many therapeutic regimens aim to modulate glucose concentrations in order to prevent end-organ damage, bariatric surgery seems to be the only treatment modality with the potential to induce complete resolution of T2DM, however the mechanisms underlying this process remain elusive. Understanding how these surgical procedures induce sustained weight loss and resolution of T2DM holds the key to development of more directed, less invasive therapies and is one of our key research focuses. There is increasing evidence that the reduced appetite and improved glucose homeostasis observed in the early post-operative period after certain types of bariatric surgery is due to alterations in circulating gut hormones. In order to gain further understanding of these processes we undertake studies on patients undergoing bariatric surgery at UCLH. In addition, we have established a mouse model of bariatric surgery to enable us to gain further mechanistic insights.
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University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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