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ANTLER Antidepressants to prevent relapse in depression
There were over 53m prescriptions of antidepressants issued in primary care in England in 2013 and many of these were for repeat prescriptions. Antidepressants are used both for treating the acute episode and for prophylaxis of future episodes of depression, also called maintenance treatment. There is good evidence that maintenance treatment that lasts 9 months is effective. However, there is still uncertainty about long term maintenance treatment. There are therefore a substantial proportion of people taking long term maintenance treatment even though there is little evidence for its effectiveness. The proposed study will provide a valid and generalizable estimate of the clinical and cost-effectiveness of long term maintenance treatment with antidepressants in UK primary care.
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