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Quantitative Susceptibility Mapping (QSM) development and applications
Quantitative Susceptibility Mapping (QSM) - a relatively new post-processed MRI contrast mechanism - is gaining traction as a sensitive surrogate for tissue iron content. QSM is also sensitive to other chemical species such as lipids e.g. myelin phospholipids, calcium and other less abundant metals. Past studies have demonstrated the value of QSM to detect relevant processes in aging (Acosta-Cabronero et al. J Neurosci 2016; Betts et al. Neuroimage 2016), drug addiction (Ersche et al. Transl Psychiatry 2017) and neurodegenerative diseases (Acosta-Cabronero et al. Plos One 2013; Acosta-Cabronero et al. Brain 2017; Acosta-Cabronero et al. Radiology 2018). The technique commonly consists of isolating local field inductions from the phase of a gradient-echo MRI acquisition, which are then used to approximate local tissue susceptibilities. My recent work on the technical aspects of Quantitative Susceptibility Mapping has improved robustness and tissue specificity (Milovic et al. Magn Reson Med 2018a; Milovic et al. Magn Reson Med 2018b; Milovic et al. MRI 2018; Mattern et al. Magn Reson Med 2018; Acosta-Cabronero et al. Neuroimage 2018). My primary goal is to provide a validated tool for use in research, diagnostic workups and clinical trials.
1 Researchers
  • Dept of Med Phys & Biomedical Eng
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Status: Active
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