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Investigating the cellular mechanisms of cortical micro-circuit behaviour in Alzheimer’s disease
Short-term memory deficits are the first symptom of the late-onset Alzheimer’s disease. This progressive disease constitutes one of the most significant health problems confronting mankind in societies with an aging population. We are focused on investigating the mechanistic insights into Alzheimer’s disease using the first Knock in App mouse model developed by collaborators Profs, Takashi Saito and Takaomi Saido (RIKEN Brain Science Institute, Japan). Our objectives include bridging the gap in our understanding of pathological changes in brain circuit behaviour that leads to progressive neuronal death, and then we will then aim to manipulate specific brain cells to correct the imbalance with molecular tools and pharmacological agents to halt neurodegeneration. These are unexplored areas into the possible mechanisms of these common neurological diseases and is expected to have a wide applicability to future therapeutic settings aimed at improving human health.
1 Researchers
  • Pharmacology
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University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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