The aim of the research is twofold. First it seeks to examine and provide evidence of urban livability and health (in)equities in the context of land use and infrastructure policies in Cali, Colombia’s third largest city. The research focuses on the area of influence of the ‘Corredor Verde’, an ongoing large scale urban regeneration initiative in the city, seeking evidence of current conditions of health (in)equity and the social and spatial distribution of livability. This seeks to produce an evidence base for future health assessments of land-use and urban interventions and policies, as well as the monitoring of the ‘Corredor Verde’ in future phases of its development. Second, the research seeks to spark a dialogue regarding practices and challenges for planning and assessing healthy urban environments that can resonate with growing debates about urban health in Latin America. Such a dialogue will build on local evidence gathered for this research, and the analysis of the potential of the ‘Corredor Verde’ to address health equity through workshops and debates with local practitioners from a range of disciplines and stakeholders in Cali. The research will draw on qualitative and quantitative evidence, with case studies in both high and low-income areas adjacent to the ‘Corredor Verde’ with different characteristics in relation to the social determinants of health.