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NO influences chromatin remodeling in neurons
We recently showed that nitric oxide (NO) influences CREB-dependent transcription by directly nitrosylating histone deacetylase 2 (HDAC2) and thereby altering chromatin acetylation. We have now found that neurorotrophins induce HDAC2 nitrosylation and have identified the cysteines in HDAC2 that are modified by NO. These exciting findings offer a wealth of potential research directions, and we will focus on the following ones. • To characterize the physiological significance of HDAC S-nitrosylation in vitro • To generate knock-in and conditional knock-out transgenic mice • To perform a comprehensive screen to identify the nuclear targets of NO • To identify genes regulated by NO during neuronal development and following behavioural stimulation in vivo
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