UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Salt, diet and hypertension: an integrative in vivo physiological investigation of WNK pathway-controlled renal electrolyte and blood pressure homeostasis
The WNK (With No Lysine[K]) pathway presents exciting new targets for treating high blood pressure (hypertension), which contributes to ~13 per cent of global deaths. Understanding how WNKs link together dietary sodium and potassium intake with the kidney’s role in balancing these salts and blood pressure control is essential to developing novel anti-hypertensive strategies. To probe the underling physiology a novel approach combining both classical and modern techniques will be utilised, namely: in vivo micropuncture and ex vivo microperfusion studies of renal tubule ion transport, intravital imaging of fluorescent dyes and genetically encoded biosensors to measure renal intracellulardynamics, and 3D imaging of optically cleared intact organs to map tubule morphology and subcellular protein expression.
5 Researchers
4 External Collaborators
 More search options
Status: Active
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by