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Salt, diet and hypertension: an integrative in vivo physiological investigation of WNK pathway-controlled renal electrolyte and blood pressure homeostasis
The WNK (With No Lysine[K]) pathway presents exciting new targets for treating high blood pressure (hypertension), which contributes to ~13 per cent of global deaths. Understanding how WNKs link together dietary sodium and potassium intake with the kidney’s role in balancing these salts and blood pressure control is essential to developing novel anti-hypertensive strategies. To probe the underling physiology a novel approach combining both classical and modern techniques will be utilised, namely: in vivo micropuncture and ex vivo microperfusion studies of renal tubule ion transport, intravital imaging of fluorescent dyes and genetically encoded biosensors to measure renal intracellulardynamics, and 3D imaging of optically cleared intact organs to map tubule morphology and subcellular protein expression.
5 Researchers
4 External Collaborators
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Status: Active
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