UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Synthesis of near IR D-luciferin analogues for imaging
Molecular imaging of living animals is crucial to allow understanding of complex biological processes, such as ageing, diseases and studying how therapies work for lifelong health. Bioluminescence imaging (BLI) exploits the remarkable properties of a firefly enzyme (Luciferase) to emit light whilst catalysing a substrate (Luciferin) to optically image biological events in living animals. BLI would be greatly enhanced if we could increase the wavelength of light emitted to infra red light, as mammalian tissues are almost transparent at these wavelengths. We synthesised an extended luciferin, infraluciferin, and found that it gave red shifted bioluminescence of ╬╗max 662 nm with wild type luciferase, which is competitive with the most red shifted analogues to date. In collaboration with Drs Pule and Jathoul (UCL Cancer) we have used a mutated luciferase that gives a maximum emission wavelength of ~720 nm. We are currently investigating the design an synthesis of other structural analogues of infraluciferin to create other red shifted and brighter luciferins.
1 Researchers
 More search options
Status: Active
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by