Funding from the EPSRC AI for science and government (ASG). Digital Twins of physical and human systems are now becoming ubiquitous in Turing’s Challenge Domains of Data-Centric Engineering, Science, and Urban Analytics. However, the increasingly widespread use of such system representations - informed by data in real-time - has yet to be accompanied by computationally efficient implementations of the leading-edge methods on High Performance Computing (HPC). We will provide systems and tools of real, practical use to researchers in these areas.