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Arterial changes in anorexia nervosa in inpatient settings
Anorexia Nervosa (AN) is a psychiatric condition leading to extreme levels of underweight and can affect children and young people. Previous research suggests that risk for cardiovascular disease (for example heart attacks or stroke) is greater in underweight people. Studies of underweight and catch-up in weight in young children have shown greater rates of cardiovascular disease (CVD) in their future. Pulse Wave Velocity (PWV) is a non-invasive and easily measured proxy for arterial stiffening and has been demonstrated to be a good predictor of future cardiovascular disease. A recent study of adolescents with AN versus controls reported greater PWV in patients with AN. This study will measure PWV in unwell children and young people with AN with underweight who have been admitted to a single specialist unit to treat AN during the initial period of re-feeding and weight gain. The study will examine for changes in arterial stiffening using PWV during the first 7 weeks of re-feeding. PWV has been measured on healthy children and young people so there is a normal range to compare the patients recruited to study, and to see how PWV changes compared the healthy population reference data. This is a pilot study to see if there are changes to inform a bigger study. This research is important as little is known about long-term physical risk from AN in children and young people, in particular how degree of underweight, and changes in weight may effect arterial stiffening.
1 Researchers
  • Population, Policy & Practice Dept
    extResource/image/01/LHUDS06
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