This work was commissioned and funded by the Foreign, Commonwealth and Development Office (FCDO), formerly DFID). The overall objective of the African Innovation Ecosystem Study (AIESyS) project was to provide a synthesis of innovation ecosystem development and support initiatives in 10 African countries: South Africa, Angola, Botswana, Namibia, Malawi, Zambia and Zimbabwe in Southern Africa; and Nigeria, Ghana and Cameroon in West Africa. It intended to support planning to improve ecosystem facilitation efforts across multiple national and regional stakeholders. The work took a wide approach to innovation ecosystems and included work beyond digital and financial sectors and innovations. Ultimately the aim was to identify ways to achieve better-connected ecosystems that deliver improved uptake of innovations and outcomes for stakeholders and best practice approaches to strengthening networks for facilitating cross-border innovation partnerships across the regions.