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The synthesis of PI 3-kinase and PKB activators and inhibitors
The project aims to identify novel PI 3-kinase and PKB activators and inhibitors to facilitate research into the role and interactions of PI kinases and is in collaboration with Dr.R.Woscholski (Department of Biological Sciences, Imperial College). Research into PI 3-kinases has benefited enormously from the availability of specific inhibitors; however, having only inhibitors greatly restricts the investigations that can be performed. Recently, compound 48/80, an oligomeric mixture of methylene linked aryl compounds, was identified as having activating properties towards PI 3-kinase. From this initial lead compound we have developed solid phase methodologies to synthesise a range of analogues and identified a novel, selective PKB inhibitor.
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