Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Anti-microbial therapies
For several years we have been investigating new anti-microbials that have novel modes of action. Four main compound-types have been explored: - Tetrahydroisoquinolines are an important set of compounds with a range of bioactivities. We have identified several of these alkaloids with anti-TB properties with a collaborator Prof S. Bahkta, and synthesised a range of compounds for anti-microbial screening with a view to probing the modes of action. Moreover we are also investigating anti-plasmodic and anti-viral properties of compounds. - The repurposing of existing drugs such as NSAID may be a valuable approach to TB-chemotherapeutics. With a collaborator Prof S. Bahkta (Birkbeck) we are exploring the SAR of a group of NSAIDs to identify compounds with enhanced bioactivities. - A new route to 1,3,5-N-alkyl pyridiniums was identified using phosphate-based media and with a collaborator Prof J. M. Ward we have established that the pyridiniums have interesting Gram-positive anti-bacterial properties. - Previously we have investigated the synthesis and biological activity of a series of calixarenes and novel small molecule analogues with anti-TB activities which appear to act via a novel host macrophage mediated mechanism.
2 Researchers
 More search options
Status: Active
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by