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Cancer Chemotherapy
Much of conventional cancer chemotherapy depends upon chemical modification of DNA, a process that often damages healthy as well as abnormal cells. Recently, a more focussed approach has been to identify a cellular enzyme whose function is necessary for oncogenic transformation, and to attempt to find small-molecule inhibitors of that enzyme. Here, we discuss new lipidic anhydrides that are selective for GGPTase, an enzyme associated with K-Ras, cell signalling, and some cancers that have been difficult to treat.
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