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Conformationally restricted peptides of defined secondary structure
We have recently developed a powerful general method for the solid-phase synthesis of peptides bearing unnatural linkages between two C a - positions. This method allows the on-resin synthesis of polycyclic peptides, which were not previously accessible, and also allows a much wider range of conformational constraints to be studied. We have so far synthesised peptides with an aliphatic linkage between the i and i+4 positions. These were designed as a -helix mimics: in contrast to the literature, however, they adopt type I b -turn conformations. We are currently synthesising peptide with different linkages in order to explore and exploit this effect .
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