UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Conformationally restricted peptides of defined secondary structure
We have recently developed a powerful general method for the solid-phase synthesis of peptides bearing unnatural linkages between two C a - positions. This method allows the on-resin synthesis of polycyclic peptides, which were not previously accessible, and also allows a much wider range of conformational constraints to be studied. We have so far synthesised peptides with an aliphatic linkage between the i and i+4 positions. These were designed as a -helix mimics: in contrast to the literature, however, they adopt type I b -turn conformations. We are currently synthesising peptide with different linkages in order to explore and exploit this effect .
1 Researchers
 More search options
Status: Active
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by