Recent work by the Task Force on Climate Change Mitigation and Public Health has found that several strategies proposed to reduce greenhouse-gas emissions have associated impacts on population health that may be positive or negative. For example, measures that advocate the reduction in the use of private vehicles in the UK have an associated health benefit from an increase in physical activity through walking and cycling. However, this may adversely contribute to an increase in road-traffic injuries. Introducing cleaner stove technology in India can be advantageous for health through a reduction in exposures to harmful combustion products, while sealing up dwellings in the UK to increase their energy efficiency may have the negative health impact of an increased exposure to indoor pollutants. The PURGE project aims to build on this work and quantify the integrated positive and negative impacts on population health and well-being of greenhouse gas reduction strategies implemented over various sectors and a range of urban settings based in Europe, China, and India. The focus will be on the sectors of energy consumption, indoor environment, transport, and food, and the work will draw on expertise from a range of departments based all over the world. This research will culminate in a specification of realistic interventions tailored to the needs of each of these urban areas to enable climate change mitigation targets laid out by the Intergovernmental Panel on Climate Change to be met at specified points in the future (2020, 2030, and 2050).