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A putative new pathway of endocytosis
Endocytosis is the process by which cells acquire substances from the extracellular space and internalise transmembrane cell surface proteins, of which receptors are a major class. The process occurs through invaginations of the plasma membrane forming endocytic vesicles that, once pinched off the surface, are transported to endosomes and, from there, sorted to the appropriated cellular destinations depending on the fate of the receptor. There are several parallel pathways of endocytosis. We recently discovered a seemingly new pathway of endocytosis. Our goal is to establish the functions and molecular mechanisms of this putative novel route of entry into cells.
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