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Development of Rapid Prototypes for Muscle Augmentation Using Magnetic Augmentation
Faecal incontinence results from defective anal sphincter muscles. It is a frequent condition, affecting 0.5 million people in UK and is associated with devastating consequences. Treatment options are limited and in general do not deliver long-term therapy. We have shown in vitro that mechanical force applied to human rectal smooth muscle cells is a growth promoting stimulus, an effect we believe can be harnessed for regeneration of sphincter muscle. Based on these observations, the aim of the project is to develop a series of prototype devices that can be used to restore continence via regeneration and conditioning of sphincter muscle. The device will apply a novel form of magnetic actuation, capable of delivering an oscillating mechanical force to sphincter smooth muscle cells. This will provide a growth promoting stimulus for sphincter muscle regeneration. The therapeutic approach offered by the proposed device is unique and offers the possibility of restoring sphincter muscle function, something that has not been achieved with existing therapies aimed at restoring continence.
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