Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Development of Genetically Modified Biological Heart Valves for Improved Durability
Degeneration of biological heart valves occurs rapidly in younger patients. As a consequence, this group of patients is often treated with mechanical heart valves which require lifetime anticoagulation. The group of Prof McGregor at the Heart Hospital, London, UK, have defined an antibody (alpha-Gal) mediated inflammatory mechanism which enhances calcification, and have developed genetically modified sources of valves which do not make the Gal antigen (GTKO). In collaboration with Dr Burriesci, they are now working on the manufacturing and preclinical testing of fixed valves from GTKO sources, to determine will determine if this material can produce a biological heart valve with prolonged durability. Such valves would advance the standard of care as they would be expected to be more durable in older patients and could be used in younger patients currently treated with mechanical valves. This would eliminate the need for lifetime anticoagulation and the related risk of thromboembolic complications for these younger patients.
3 Researchers
 More search options
Status: Active
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by