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Mechanisms underlying synapse-specific clustering of GABAA receptors
This project focuses on mechanisms underlying clustering of GABAA receptors at specific synapses. We have developed co-culture model systems in which heterologously expressed subtypes of GABAA receptors are recognized and innervated by specific types of GABAergic neurones. Immunofluorescence, live imaging, electron microscopy and electrophysiology are used to study formation of synaptic contacts and their functionality. Jovanovic & Thomson, 2011, Front Neurosci; Thomson & Jovanovic, 2010, Eur J Neurosci. (MRC UK, 2009-2013, in collaboration with Professor Alex Thomson, Professor F. Anne Stephenson and Dr Audrey Mercer)
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