The Translational Research Laboratories (TRL) have established a multi-disciplinary research programme to study the molecular genetic and biological basis of tumour development in gynaecological cancers, primarily epithelial ovarian cancer. The research programme covers epidemiology, genetic susceptibility, screening, epigenetics, molecular pathology of tumour development and cell biology. The basis for these studies is a samples collection unit (the Tumour Marker Laboratory), which has established local, national and international collections of tissue samples and data from more than 200,000 subjects. A high throughput approach to many aspects of this research has been implemented, and state of the art technologies have been established: These include high throughput robotics integrated with LIMS and samples tracking databases, automated DNA sequencing and SNP genotyping, DNA and expression microarray, proteomics and bioinformatics. The TRL is committed to establishing a translational research programme through integration with the clinical gynaecological oncology programme at UCL and UCLH. The focus of the research is prediction, prevention and treatment of gynaecological cancers. Specifically, the aims are: To identify serum markers for screening and early detection of gynaecological cancers To identify markers of genetic susceptibility for risk prediction and intervention for ovarian cancer To identify markers of tumour development and clinical outcome in gynaecological tumours for improved prognosis and clinical management of disease Click on any of the links on the left of the page to learn more about any aspect of our research programme