Prenatal diagnosis and therapy have been a mainstay of Obstetric research at UCL since 1990, when Professor Charles Rodeck was appointed, who had an international reputation for pioneering work developing ultrasound-guided invasive procedures, such as fetal blood transfusion. Professor Rodeck retired in 2007, but previously led the Serum, Urine and Ultrasound Screening Study (SURUSS), assessing novel methods of Down syndrome screening, some of which are now incorporated into the protocols recommended by the National Institute for Clinical Excellence (NICE).