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Macromolecular Bioprocessing

Research in Macromolecular Bioprocessing is headed by the EPSRC Centre for Innovative Manufacture in Emergent Macromolecular Therapies hosted in the Department of Biochemical Engineering with collaboration from across UCL (Schools of Pharmacy, Dept. of Chemical Engineering, Dept. Public Health Economics) and from Imperial College (Dept. Chemical Engineering). The focus is to create a set of methods and tools by which early identification of a new molecule's ease of manufacture can be assessed alongside clinical effectiveness and costs of manufacture and also the cost of delivery to the patient. The ultimate objective is to achieve efficient conversion of potent new therapies to the patient at a cost which the NHS can afford. Centre studies are complemented by work to consider the ways in which bioprocesses are developed for the manufacture of complex and highly specific next-generation biopharmaceuticals. Activities include host cell engineering to overcome process bottlenecks, the creation and use of automated microscale bioprocessing techniques and modelling tools for intelligent experimentation and rapid bioprocess optimisation. Additional studies include the assessment of alternative manufacturing strategies for the production of new molecules and embrace options such as continuous processing and the application of single use routes to industrial practice. The use of advanced facilities to examine scale-translations underpins the work in the research group.

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