Despite strength in the basic sciences UCL had not had a major focus on clinical nutrition, but this has changed with the creation of one of the UK’s busiest clinical services in nutrition and intestinal failure at UCH. Work includes that on the underlying biology of intestinal fistula and intestinal adaptation, as well as evaluation of pre- and pro-biotics. Collaborations are currently mainly outside UCL (King’s College London, University of Parma, University of Warsaw) but an NIHR-supported initiative is greatly enhancing the links to UCL Hepatology and study of the interface between intestinal function and liver failure.