The Molecular Haematology and Cancer Biology Unit comprises a wide range of approaches to understanding the molecular aetiology of cancer. We are expert in technologies as diverse as generating transgenics, cloning cDNAs from differential expression screening, proteomics, using Affymetrix DNA chip microarrays and single cell microinjection. A central theme of the Unit is studying the basic mechanisms of apoptosis as well as its role in the development of cancer. The major areas of interest in our research ie childhood leukaemia, bone marrow failure and neuroblastomas reflect the major disease types treated by the haematology and oncology clinicians at Great Ormond Street Hospital. A major aim of the close relationship between clinicians and scientists is to translate discoveries from the lab into the clinic.