Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Inflammation and dyslipidaemia
Inflammation and dyslipidaemia co-exist in patients with chronic kidney disease. This project examines how these two factors may interact to contribute to progression of kidney injury and the premature development of arterial disease. Our results show that inflammatory cytokines disrupt intracellular lipid metabolism thereby causing intracellular lipid accumulation (foam cell formation). This is the result of both excess lipid uptake and impaired lipid export from the cell. On-going work is investigating the mechanisms by which a cell is able to "sense" its intracellular lipid cholesterol level and respond accordingly, a process that involves sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP). Importantly, pharmaceutical compounds that stimulate peroxisome proliferator activator receptors (PPARs) appear to protect against intracellular lipid accumulation. Dr Zac Varghese is also involved in studying the involvement of lipids in chronic allograft nephropathy and the anti-inflammatory and anti-atherosclerotic effects of specific immunosuppressive drugs.
2 Researchers
 More search options
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by