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Translational Immunotherapy
The Group’s interests centre on the study of the immunology of bone marrow transplantation incorporating immunotherapy, immune reconstitution and graft-versus-host disease (GvHD) with a special focus on translational research. Currently the group is responsible for 4 phase I or II clinical trials including a completely novel natural killer cell therapy which is being trialled in patients with AML. The group identifed a previously unknown tumour-restricted pathway for NK cell activation and translated this into a clinically-relevant procedure which was finally approved by the MHRA for phase I trial. NK cells activated in this manner do not target allogeneic normal cells/tissues but are highly cytotoxic to many haematological cancers and some solid tumours including breast and ovarian cancer cells. Additionally the group is running a phase I/II trial of CMV-reactive allogeneic T cells to prevent/treat CMV reactivation post haematopoietic stem cell transplant. Preliminary data have been published and have led to a Wellcome Trust funded phase III multicentre trial in conjunction with a UK biopharma company. The group controls a dedicated “clean room” facility for the production of cell therapies as “investigational medicinal products” for clinical trials under licences from the Human Tissue Authority and the Medicines & Healthcare Products Regulatory Agency. The group has now realised the UCL-Royal Free BioBank at the Royal Free campus
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University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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