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Cell Cycle Control
Our bodies are composed of many millions of individual cells and each cell inherits genetic information through ordered cell cycle events including DNA replication and chromosome (DNA) segregation. Cancer is a disease of cells causing uncontrolled cell division. Therefore, a full understanding of the mechanisms underlying cell cycle control is required for the fight against cancer. We are studying how cell growth and the cell cycle are controlled by ubiquitin-mediated proteolysis. We are in particular focusing on a key enzyme called the anaphase-promoting complex/cyclosome (APC/C), which plays an essential role in dividing and non-dividing cells.
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Current Research Activities
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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