Our bodies are composed of many millions of individual cells and each cell inherits genetic information through ordered cell cycle events including DNA replication and chromosome (DNA) segregation. Cancer is a disease of cells causing uncontrolled cell division. Therefore, a full understanding of the mechanisms underlying cell cycle control is required for the fight against cancer. We are studying how cell growth and the cell cycle are controlled by ubiquitin-mediated proteolysis. We are in particular focusing on a key enzyme called the anaphase-promoting complex/cyclosome (APC/C), which plays an essential role in dividing and non-dividing cells.