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Renal physiology
The group is broadly engaged in studies of renal tubular transport physiology and pathophysiology, including clinical tubulopathies (especially inherited forms associated with renal stone disease). A specific area of interest is the potential for an 'intracrine' regulatory system of renal tubular fluid and solute transport that is dependent on the bioactive components of tubular fluid, such as small peptides (including cytokines) and nucleotides (such as ATP). On-going studies are focused on the handling of filtered low molecular weight proteins and peptides in the Fanconi syndrome, and application of proteomic methods to determining tubular fluid composition. The group is also studying the nature of proteins expressed in the proximal tubular cell membrane, and is characterising the ATP-sensitive P2 receptor system along the renal tubule. Additional studies are investigating the intestinal transport of phosphate in renal failure, as a potential therapeutic target to prevent hyperphosphataemia.
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