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Publication Detail
The role of concentration-effect relationships in the assessment of QT(c) interval prolongation
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Publication Type:Journal article
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Publication Sub Type:Review
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Authors:France NP, Della Pasqua O
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Publisher:WILEY
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Publication date:01/01/2015
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Pagination:117, 131
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Journal:BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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Volume:79
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Issue:1
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Status:Published
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Print ISSN:0306-5251
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Language:English
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Keywords:Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, cardiovascular safety, clinical trial simulations, drug development, ICH E14, PKPD modelling, QT(c) interval prolongation, DRUG-INDUCED PROLONGATION, INDUCED QT PROLONGATION, TORSADE-DE-POINTES, POPULATION PHARMACOKINETICS, PARAMETER-ESTIMATION, TRIAL SIMULATION, CLINICAL-TRIALS, THOROUGH QT, SAMPLE-SIZE, SAFETY DATA
Abstract
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