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Publication Detail
Personality traits are differentially associated with patterns of reward and novelty processing in the human substantia nigra/ventral tegmental area.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Krebs RM, Schott BH, Duzel E
  • Publication date:
    2009
  • Pagination:
    103, 110
  • Journal:
    Biological Psychiatry
  • Volume:
    65
  • Issue:
    2
  • Print ISSN:
    0006-3223
Abstract
The long-standing observation that novelty-seeking personality trait is a predictor of drug use and other reinforcable risky behaviors raises the question as to how novelty and reward processing functionally interact in mesolimbic dopaminergic circuitry and how this interaction is modulated by the novelty-seeking personality trait. Methods: Functional magnetic resonance imaging (fMRI) hemodynamic responses to novelty and reward (monetary incentive) from the substantia nigra / ventral tegmental area (SN/VTA) as well as from nucleus accumbens (NAcc) and hippocampus of 29 subjects were correlated with novelty-seeking scores.These correlations were compared to those obtained for scores of reward-dependence. The fMRI data were taken from two experiments in which the interaction of novelty and reward was manipulated as a within-subject variable and long-term memory for the critical stimuli was assessed after 24 hours. Results: Novelty-seeking was positively correlated with SN/VTA activation elicited by novel cues that did not predict reward, while reward-dependence was related to activations elicited by novel cues that predicted reward. The positive correlation between SN/VTA responses to novelty and novelty-seeking scores was accompanied by a negative correlation with reward-related SN/VTA activation and memory enhancement. Conclusions: The SN/VTA responses to novelty and reward are differentially affected by personality traits of novelty-seeking and reward-dependence. Importantly, novelty-seekers were more responsive to novel cues in the absence of reward and needed less reward to boost their memory for novel cues. These observations strongly suggest that for novelty-seekers, the motivational value of novelty is not necessarily based on actual reward-predicting stimulus properties.
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