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Publication Detail
TMS evidence for smooth pursuit gain control by the frontal eye fields.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Nuding U, Kalla R, Muggleton NG, Büttner U, Walsh V, Glasauer S
  • Publication date:
    2009
  • Pagination:
    1144, 1150
  • Journal:
    Cerebral Cortex
  • Volume:
    19
  • Issue:
    5
  • Print ISSN:
    1047-3211
Abstract
Peculiar property of the smooth pursuit eye movement system is the non-linear increase in sensitivity to retinal image motion with increasing pursuit velocities. We investigated the role of the frontal eye fields in this dynamic gain control mechanism by application of transcranial magnetic stimulation. Subjects were required to pursue a moving target whose motion consisted of two components: (i) a constant velocity component at four different velocities (0, 8, 16, and 24 deg/s) and (ii) a superposed high frequency sinusoidal oscillation (4 Hz, ±8 deg/s). Stimulation of the frontal eye fields reduced not only the overall gain of the system, but also the efficacy of the dynamic gain control mechanism. We therefore provide the first direct evidence that the frontal eye field population is significantly involved in the nonlinear computation necessary for continuously adapting the feed forward gain of the pursuit system.
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