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Publication Detail
Interventional photoacoustic imaging of the human placenta with ultrasonic tracking for minimally invasive fetal surgeries
  • Publication Type:
  • Authors:
    Xia W, Maneas E, Nikitichev D, Mosse C, Sato dos Santos G, Vercauteren T, David A, Deprest J, Ourselin S, Beard P, Desjardins A
  • Publisher:
    Springer International Publishing
  • Publication date:
  • Place of publication:
    Cham, Switzerland
  • Published proceedings:
    Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2015 18th International Conference, Munich, Germany, October 5-9, 2015, Proceedings
  • Series:
    Lecture Notes in Computer Science (LNCS)
  • Editors:
    Frangi A,Hornegger J,Navab N,Wells WM
  • Status:
  • Name of conference:
    MICCAI 2015, the 18th International Conference on Medical Image Computing and Computer Assisted Intervention
  • Conference place:
    Munich, Germany
  • Conference start date:
  • Conference finish date:
  • Addresses:
    Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Image guidance plays a central role in minimally invasive fetal surgery, such as photocoagulation of inter-twin placental anastomosing vessels to treat twin-to-twin transfusion syndrome (TTTS). Fetoscopic guidance provides insufficient sensitivity for imaging the vasculature that lies beneath the fetal placental surface due to strong light scattering in biological tissues. Incomplete photocoagulation of anastamoses is associated with postoperative complications and higher perinatal mortality. In this study, we investigated the use of multi-spectral photoacoustic (PA) imaging for better visualization of the placental vasculature. Excitation light was delivered with an optical ber with dimensions that are compatible with the working channel of a fetoscope. Imaging was performed on an ex vivo normal term human placenta collected at Caesarean section birth. The photoacoustically-generated ultrasound signals were received by an external clinical linear array ultrasound imaging probe. A vein under illumination on the fetal placenta surface was visualized with PA, and good correspondence was obtained between the measured PA spectrum and the optical absorption spectrum of deoxy-genated blood. The delivery ber had an attached fiber optic ultrasound sensor positioned directly adjacent to it, so that its spatial position could be tracked by receiving transmissions from the ultrasound imaging probe. This study provides strong indications that PA imaging in combination with ultrasonic tracking could be useful for detecting the human placental vasculature during minimally invasive fetal surgery.
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Dept of Med Phys & Biomedical Eng
Maternal & Fetal Medicine
Dept of Med Phys & Biomedical Eng
Dept of Med Phys & Biomedical Eng
Dept of Med Phys & Biomedical Eng
Dept of Med Phys & Biomedical Eng
Dept of Med Phys & Biomedical Eng
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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