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Publication Detail
Grey matter sublayer thickness estimation in the mouse cerebellum
  • Publication Type:
    Conference
  • Authors:
    Ma D, Cardoso MJ, Zuluaga MA, Modat M, Powell N, Wiseman F, Tybulewicz V, Fisher E, Lythgoe MF, Ourselin S
  • Published proceedings:
    MICCAI 2015
  • Editors:
    Frangi ,Homegger ,Navab ,Wells
  • Name of conference:
    Da Ma
  • Conference place:
    Munich, Gemany
  • Conference start date:
    05/10/2015
  • Conference finish date:
    09/10/2015
  • Keywords:
    cerebellum, sublayer, thickness, Purkinje layer
Abstract
The cerebellar grey matter morphology is an important feature to study neurodegenerative diseases such as Alzheimer's disease or Down's syndrome. Its volume or thickness is commonly used as a surrogate imaging biomarker for such diseases. Most studies about grey matter thickness estimation focused on the cortex, and little attention has been drawn on the morphology of the cerebellum. Using ex vivo high-resolution MRI, it is now possible to visualise the different cell layers in the mouse cerebellum. In this work, we introduce a framework to extract the Purkinje layer within the grey matter, enabling the estimation of the thickness of the cerebellar grey matter, the granular layer and molecular layer from gadolinium-enhanced ex vivo mouse brain MRI. Application t
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Dept of Med Phys & Biomedical Eng
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Neurodegenerative Diseases
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Dept of Med Phys & Biomedical Eng
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Dept of Med Phys & Biomedical Eng
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Neurodegenerative Diseases
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